Physicochemical properties and cytochromes P-450 kinetics of a trifluoroacetamido derivative of acetaminophen
Acetaminophen (N-acetyl-para-aminophenol, APAP) is a commonly used analgesic and antipyretic drug.While acetaminophen is generally safe when taken at therapeutic doses, it causes severe liver and kidney damage at overdose quantities.Cytochromes P-450 (CYP) Kitchen Linen catalyze the transformation of APAP to N-acetyl-p-benzoquinone imine (NPAQI), a