PHYSICOCHEMICAL PROPERTIES AND CYTOCHROMES P-450 KINETICS OF A TRIFLUOROACETAMIDO DERIVATIVE OF ACETAMINOPHEN

Physicochemical properties and cytochromes P-450 kinetics of a trifluoroacetamido derivative of acetaminophen

Acetaminophen (N-acetyl-para-aminophenol, APAP) is a commonly used analgesic and antipyretic drug.While acetaminophen is generally safe when taken at therapeutic doses, it causes severe liver and kidney damage at overdose quantities.Cytochromes P-450 (CYP) Kitchen Linen catalyze the transformation of APAP to N-acetyl-p-benzoquinone imine (NPAQI), a

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A new approach for detecting adventitious viruses shows Sf-rhabdovirus-negative Sf-RVN cells are suitable for safe biologicals production

Abstract Background Adventitious viral contamination in cell substrates used for biologicals production is a major safety concern.A powerful new approach that can be used to identify adventitious viruses is a combination of bioinformatics tools with massively parallel sequencing technology.Typically, this involves mapping or BLASTN searching indivi

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Accurate Sex Identification of Ancient Elephant and Other Animal Remains Using Low-Coverage DNA Shotgun Sequencing Data

Sex identification of ancient animal biological remains can benefit our understanding of historical population structure, demography and social behavior.Traditional methods for sex identification (e.g., osteological and morphometric comparisons) may be ineffective when animal remains are not well Insulated Covers preserved, when sex distinguishing

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Passenger terminal extension structure at Split Airport

The main load-carrying structure, to be built as an extension to the passenger Solder Paste terminal building at Split Airport, is presented in the paper.The structure is complex and comprises various types of facilities (building, bridge, membrane shed), various load-bearing systems (space truss, space frame, dome, tensioned cable, tensioned membr

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Infrastructure Indices: Comparative Analysis of Performance, Risk and Representation of Global Listed Proxies

Faced with historically low interest rates, Bundles investors are looking further into illiquid assets such as infrastructure in search of alternative sources of income, better diversification and a long-term investment perspective.This paper analyzes the key performance and risk characteristics of the EDHECinfra global unlisted infrastructure equi

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